【About Company】
- Backed by a premier, listed Chinese pharmaceutical leader, this biotech platform operates as a strategic "Special Innovation Zone" for high-impact R&D. The company manages a robust pipeline spanning small molecules, ADCs, and siRNA, with key assets already achieving significant global out-licensing success. By combining the massive financial stability of its parent company with the agility of a high-growth biotech, it offers a secure yet fast-paced environment for scientific leadership. With a focus on advancing proprietary candidates through IND submission, the organization provides immense potential for professionals to drive trans-formative medicine on a global scale.
【Job Details】
- Position: Head of Medicinal Chemistry (Small Molecule)
- Location: Shanghai
- Budget: 1.0M - 1.2M
- Core Focus: Small Molecule Innovative Drug R&D
【Job Overview】
- The Director of Medicinal Chemistry will spearhead the small-molecule R&D strategy in Shanghai, leading a high-performing team to advance projects from hit identification through PCC selection to IND submission. This role requires a blend of deep scientific expertise and strategic leadership within a fast-paced, innovation-driven environment.
【Key Qualifications】
- Education: Ph.D. in Organic or Medicinal Chemistry.
- Industry Experience: Minimum 8 years of experience in small-molecule drug discovery within Multinational Corporations (MNCs) or top-tier industry leaders.
- Track Record: Must have direct experience advancing at least one project to PCC and a proven track record of successful IND submissions.
- Leadership: Prior experience managing a medicinal chemistry team of at least 5+ members.
【Core Responsibilities】
- Strategic Leadership: Formulate and execute R&D strategies; make critical decisions on project direction, resource allocation, and risk management.
- Innovative Molecular Design: Lead SAR optimization and molecular design based on structural biology and computational chemistry.
- Advanced Technologies: Apply cutting-edge modalities such as PROTACs, covalent inhibitors, and AI-assisted drug design to enhance discovery efficiency.
- Cross-functional Collaboration: Partner with Biology, DMPK, and Toxicology teams to balance physico-chemical properties and ADMET profiles.
- Team Development: Recruit, mentor, and motivate a team of chemists, ensuring the highest standards of scientific rigor and data quality.
【Technical Competencies】
- Profound understanding of molecular design, drug-likeness, and complex chemical optimization challenges.
- Proficiency in modern organic synthesis and structure elucidation. Strong project management skills with a results-oriented and "challenge-the-status-quo" mindset.
